So far Suros Regime is my best weapon, however over the course of the game the trusty scout rifle has acted as the weapon making the most kills, and getting me out of the most jams. When things got really rough though, a rocket launcher like Unfriendly Giant dropped the bad guy. I have yet to level up Ice Breaker, and Patience, and Time. I like snipers, but they do have limits. Red Death has killed me leveling it up almost as much as Universal Remote did, but Red Death seems like the better weapon. At first I used mostly hand cannons, but until I get an exotic I will be lukewarm on them. I am currently running Red Death, Prudence ll and Admonisher all at 331.