This includes fantasy and sci-fi.
My choice is the Combine.
A multi-universal species from half-life so absolutely immense and powerful that they reverse-engineered earth's technology, upgraded far beyond human ability, brainwashed some humans and had them invade themselves. They did this and stomped all resistance within 7 hours. This was done by a backwater lesser combine city mind you.
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Children in skyrim. They are immortal.
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I hate to do this but [spoiler]the vex. They can erase you from time[/spoiler]
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I hate to say it, but...[spoiler]The Vex. Because the oracles just erasing you before you happen.[/spoiler]
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Unicron from Transformers. Damn near unkillable (seriously, he's been decapitated, blown to pieces, had his spark extinguished, etc. and it's only slowed him down), the Transformers equivalent of Satan, unbelievably ancient, "blood" is capable of raising an undead army of Transformers, turns into a planetoid that literally eats other planets, has an insatiable hunger, despises any and all living things, etc.
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Nаzis
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[url=http://www.wikipedia.org/wiki/Godwin%27s_law]-godwinslaw!-[/url]
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Whiterun guards. They never stop coming.
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Aerdra
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Prescusors
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Ewoks
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The creatures from dead space because they never go away.
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Tyranids from what i know they EAT -blam!-ING PLANETS
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The Lenny Sovereignty Unstoppable. Relentless. [spoiler]( ͡° ͜ʖ ͡°)[/spoiler]
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Whatever Kirby is. OP AS PHUCK
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Smurfs
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The aliens from the book the fifth wave
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Grunts [spoiler]Dragon born[/spoiler]
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The Flood. Why? Because the Forerunners were sore losers and nuked basically the ENTIRE UNIVERSE to beat them.
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Your friends
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Black people
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Boobs
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Precursors
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The flood nuf said
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The necromorph from dead space because they actually won the game
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Mario