Ok in Borderlands as you level up(all the way to 72) you gain more health and can use bigger shields. Instead of damage scaling(what destiny does), the numbers just get bigger. A level 72 Vault Hunter with ~160,000 health could easily take on a level 32 Guardian with ~200 health. Also, a lot of the legendary gear in borderlands have [b][i]VERY[/i][/b] unique and game changing perks.
[spoiler]Plus infinite ammo glitch on a Jakob's Quad Shotgun with potentially infinite Evil Smasher stacks and Anarchy class ability melts through health bars faster than you can blink.[/spoiler]
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Don't forget to use a Bee with that Hyperion quad with the buck up glitch, and evil smashed to hell lol
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You can definitely get more than 160,000 health by lvl 72. Plus the shields can get to ridiculous ranges.