You see, here is the problem, you want to take this universe and compare it to some other universe in the first games universe. Let's just compare them in this universe shall we? Let's not look at abilities or guns and let's focus on what matters. No matter how strong you are, if you have no brain, then you are not dangerous. I am saying the guardians would win, because they are smart enough to understand simple concepts like, not setting off a nuke 10 feet away from yourself. See, your vault hunter just killed himself and my guardian is sitting comfortably in orbit right now laughing at how stupid you vault hunter is. It doesn't matter if you have all the power in the entire u overseas if you are too stupid to understand the consequences of using it. Guardians are people who use their minds and vault hunters are just brutes. Let's face it, even you agree if you would brought the gunzerker into this.