Okay well.. Depends on what universe they fight in. I think home field advantage decides the fight. In DBZ universe, Goku would just go somewhere secluded and spirit bomb the -blam!- out of them. He knows the terrain better than the guardians. Even if he is killed, he isn't defeated because someone will be there to collect dragonballs. In Destiny universe, Goku would probably go super saiyan 863, then some sunsingers would rush him with matadors because there's no way Goku would know to research his enemies. The sunsingers would die, defenders would pop their bubbles, golden guns would cheese out of the bubbles, once those are gone, the strikers will rush in with bladedancers in front of them, and when they get close the sunsingers will self-res from behind, wail grenades at his back, then the bladedancers and strikers would reach him, annihilate him, and fire some gjallarhorns at his body just in case. No dragonballs, no self-res. game set match.