You don't actually have to be stronger to beat someone. But if we aware judging by strength, Master Chief would win.
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Although you're right on not needing to be stronger to win, master chief still wouldnt stand a chance against guardians. Here's why. -Chief has inhuman reflexes? So do guardians, but they don't have organic muscles to slow them down, so they could even be faster. -Chief would get unfairly overpowered, in a close range match against all but hunters (who would need to rely on their speed more). -Chiefs normal weapons (BR, magnum, etc), and grenades would be no match for a guardians high tech weaponry, and light grenades (which also regenerate). Guardians > Spartans