I've got to say, this one is definitely my favorite.
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Halo CE magnum Nuff said
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Magnum from halo 3
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Might be a long list: The .357 from Half Life 2 Dual Wielded rapid fire .44s from MW2 .44 Magnum from BF4 (my dearest friend) .44 MEGA Class from Marathon. The First Masher I ever got in Borderlands. The Law Revolver from Borderlands 2. The Devil You Know from Destiny. Boltok from Gears of War.
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The one that goes boom
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The one that's to OP in the crucible
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The last word
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Any masher in Borderlands (1)
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The one from Bioshock Infinite. It was a monster
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BANG BANG BANG BANG
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The hand cannon. From resident evil 4. Basically a 1 shot magnum to all normal enemies. Unlocking it was super damn worth it. (Re4 on hard mode. Wahhh. All the game overs. )
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Assassin's creed 2 hidden gun
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The Killer7 from RE4
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44. Magnum in any game.
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.44 Magnum from BF4. Thing's a damn monster.
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The ol' 44 Magnum from BF3, just didn't feel right in BF4 but in BF3? Oh man was it awesome.
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Any Juan Deag Or the 44
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MUSTANG N' SALLY!
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Devil you know. Too bad it's going bye bye
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Fatebringer
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The mighty Paddywhacker.
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Bang, bang, bang. Pew, pew, pew, pew! The Deagle Cod4
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Ezio's dual pistols from Brotherhood.
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Unkempt Harold. No question.
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The Boner
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Double Penetrating Unkempt Harold is love
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Thorn hands down