This has been my experience thus far:
Me: Ok. My settlement is nicely built up for now. Time for some quests.
*walks towards active quest location*
Me: Oh look! Another settlement location.
*several hours later*
Me: Ok. This settlement is nicely built up for now. Time for some quests.
*walks toward active quest location*
Me: Oh look! Another settlement location.
*several hours later*
Me: Ok. This settlement is built up nicely for now. Time for some quests.
*walks toward active quest location*
Me: Oh look.....
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I decided to go with just one settlement at sanctuary. I scrapped everything I could except for stations and tvs. Working on building a steel wall all the way around it. I can't spend more than an hour in building mode though. Too many things to shoot and loot out there.