A smash sends a compression wave moving at the speed of sound throughout an object. Supposing you are smashing a keyboard, yes, you can. Now suppose there is a super compressed substance in front of you. Granted, it would likely form a singularity and explode, (due to hawking radiation) causing a blast that would instantly destroy you. Lets assume that that did not happen. First, smashing it would be nearly impossible. Depending on the density of the material, different forces would be necessary for that to happen. A possible force you could apply to 'smash' it could be pressure. Already, this exerts intense pressure. It's gravitational pull might actually be able to overcome the vibrations of the super heated atoms, rendering it odorless and incapable of filling space. Putting the material underneath Jupiter's atmosphere would not be enough to crush it (despite the atmosphere being heavy enough to solidify hydrogen, which is no small feat). Putting the material inside a neutron star might be able to crush it, but doubtfully. A neutron star is incredibly dense and contains an incredible amount of mass, but I doubt it would be enough. The closest you could get is by introducing it to another black hole. If it is big enough, it might be able to compress the material enough to count. So yay! You smashed!