You don't need to just follow the markers and play objective to objective. Join factions, do side quest, explore, etc. It increases replayablity, fun, you will also level up faster and find more secrets that you would never normally find.
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Edited by S0da Bomb250: 11/22/2015 7:49:09 PMThe glowing sea is a pretty cool place to find cool stuff (southwest corner of the map). Just be higher level with a hazmat suit, power armor, and lots of stimpacks, rad-x, and Radaway
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The Glowing Sea is in the SW corner.