At least the lives of gen 3 synths. They have a free will, consciousness and emotions just like humans.
But on the other hand. They can be a serious threat to humanity. They are artificial. They are not created by nature. They have no soul. Or have they?
I always find myself on the fence.
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I promote equality for synths. The institute treats them as slaves and the brotherhood off steel treats them as mindless lunatics. I'm very much against both factions. However, I'm not willing to give my life to save a synth. At the end of the day, they are still just machines. If one dies, a perfect copy can be made. If I die, I can never be replaced.