Well for me it's the time a clafairy used roar of time on me caused me to lose[spoiler]spelling correctly disabled [/spoiler]
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When you accidentally kill a shiny pokemon that you've been trying to catch or it ran away or something. When your fighting the champion you both have 1 pokemon and you got no moves left, status affected while confused and you have no healthy potions or revives and your final pokemon health bar is on the red Lol