If someone says something offensive to you, just don't give a f*ck. Don't take it seriously, just know that they're the one in the wrong. You'll live your life a lot happier.
My friend is 6'5" and Chinese, and she doesn't take no shits from anyone. She's completely different in looks from everybody yet she's one of the most respectable people I know.
Long story short, sticks and stones.
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Hell, [i]I'm[/i] autistic (on a very minor spectrum), and I'm not even offended by autism jokes; we all know that they're just tactics to get volatile emotions out of people.