I don't believe anyone has said it yet, but how about adding a separate control for the Hunter melee?
As a Nightstalker, too often have I tried to (strictly) melee an enemy at close range and ended up throwing a smoke/poison grenade. The same applies for the Gunslinger Hunter when I've tried to melee and threw a throwing knife past my enemy's head instead.
These situations usually leave me spamming my X button to respawn as opposed to walking away from the encounter victorious and eager for the next run-in. An independent key to ensure that you're throwing a projectile rather than trying to melee would benefit Hunters everywhere.
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Not to mention the gunslinger loosing his knife on a miss but a warlock and titian keeping theirs. A Titan would be far less likely to use shoulder charge as a gap closer if they lost the charge like a hunter throwing away a dagger.