Like I been thinking about this for so long, how would Guardians fight the Reapers? What can we even do to them?
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I'm assuming the paracausal powers that make the Guardians immune to being taken would also help keep them from being indoctrinated (i think that's the right word, haven't played Mass Effect in forever). I'd say boarding action, try to destroy the Reapers from within. Go for the heart, like the derelict from ME2.