T4R
Mine was when I was 13. My older brother and I have a sleepover with two of our cousins, but our aunt and uncle didn't want us keeping the family awake all night with our Halo 3 and Halo 2 shenanigans. So we got a kerosene heater, went to the barn, brought the big ass CRT TV with us, and played halo. Four way split-screen. It was Fall, so we were breathing in nasty kerosene smoke to stay warm.
The next day our eyes hurt, and my older brother kept showing me the black snot that he was blowing out...
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I imagine some mobile gaming experiences might be pretty wild :)
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Probably when I was playing MW3 with my friend at his house in their new game room. The furniture was nice and they had a small mini-fridge with drinks, but the furniture smelled like horrible cigarettes for the whole time their. I got used to it but it kept giving me a horrible headache that I would sleep off quickly then jump back in before it came back. We also got two boxes of swiss rolls and bazooka so all of that chewing added on to my headache as well. I noticed the smell less and less the more I came over to his house so it didn't bother me as much anymore.