Where do you want it to be? My vote is for a full on modern day game with desmond or one set in feudal japan (ninjas and samurai galore)
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Hopefully they drop the entire "I'm a future person reliving my ancestor's memories in an attempt to figure out stuff relevant to the future!" frameworking, because although that was a whimsical way to frame the first and second game, it quickly got old when every single thing that his Ancestors did had to be relevant to a world hundreds of years later.