I stick to whatever is most comedic or interesting, such as running into rooms with a shotgun firing in a way that syncs to the tune of "Banana Phone". as for moral compus, I might as well be in the center of the earth. I shoot through hostages, burst into rooms to only shoot those I'm supposed to save. And if the morally bad choice gives me something cool I'll take it, then turn to the guy giving it to me and bash his head in with it.
Although sometimes I try to be good, does not last.
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I usually play as though it were real and that's what I'd actually do. So a "good guy" playthrough. Though in Skyrim I did a playthrough with an "evil" character. Ended up only being like half evil.