Clearly there are some drawbacks to some of them, but alcohol and tobacco worse than some of them. Just think about it; it all comes down to personal responsibility so why prevent others from being happy? If you don't feel like smoking crack then don't, but don't stop another from wanting to satisfy themselves.
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I don't mind regulating use of drugs based on how addictive they are-- not that I know where the line should be drawn. While someone might have felt like using the drug at some point, addiction can be a lifelong struggle. It can be hard to understand addiction's effect, especially if the circumstances when you started using a drug were less than ideal. Even the best of us don't act in a purely logical manner, free of the constraints of feelings and emotions and pressures, and there are some punishments that don't fit the crime. That being said, I have very limited knowledge about substances and their addictive properties. From what I can see, marijuana is safe enough that it should be legalized. A lot of it is cultural; we like alcohol and tobacco because they've stuck around long enough to be a part of mainstream culture (though tobacco has been marginalized).