The Wii U is actually somewhat more powerful than the X360 and PS3, so it would look and play the same as on those. It's just Nintendo's online service that would prevent it.
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The Wii U is the next gen Nintendo, so technechly speaking, it's not very powerful. And it's not just the online service, but the controller too.
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Well, yeah, it's less powerful than the X1 and the PS4, but considering Destiny was benchmarked on the X360 and PS3, Destiny would be fine. The controller I'm not going to argue about with you in terms of whether it's good or not, because with the controller it's really a matter of opinion. However, I do not believe it would hinder gameplay in any way. Why do you say it will?