I've always wondered.
Example:
My friend: The Phillies finally scored a run.
Me: Thank God!
English
#Offtopic
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It's just an expression, so no. I say "Oh my god" sometimes, and I'm not religious. If someone were to say "God gave you this talent" about something I'm good at however, I would be offended. I wasn't given anything, I gained it by practice.