The hand canon could use a little tweak. I love the idea of being dirty harry and just blowing dregs away, but instead of asking them if they feel lucky it's more like if I feel lucky. It just can't compete with the rifles.
It just doesn't belong in the primary slot. Put it in the special weapon slot and buff its damage. Its a skill weapon with a low amo count, and it a good medium range weapon between the shotgun and sniper. It belongs there and them maybe it can get the love and respect it deserves. =)
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Lets be honest, I wouldn't use the hand cannon over an auto or scout rifle, however, it it was made a special weapon (because big A$$ revolvers are secondary weapons) and it had a damage and reload speed buff, I would use it over a fusion rifle, shotgun and sniper rifle in situations when none of those weapons will help, for example, you want to have another weapon similar to a primary but has a different ammo pool, then just pull out your hand cannon