One of the first disappointments with Fallout 3 is that I couldn't drive a motorcycle or car.
There are destroyed vehicles [b]everywhere[/b], and people have the technology to make robots, yet nobody has made a functioning motorcycle or truck. Logic.
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I don't necessarily think that vehicles would really be a good addition to Fallout 4, it would cut back with exploration. But maybe something like a Brahmin train or a mutated horse.