What is your most gut wrenching, tear jerking, memorable moments from any game? Halo 4 when chief watched as his possibly only friend that had stuck with him through it all was slowly destroyed by an unforeseen force and he could do nothing as she disappeared into nothing, or when he had to leave that very same friend in the slimy hands of the grave mind.
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Having to kill Solaire in Dark Souls 1 because I didn't give enough offerings to a certain covenant to open the shortcut to an area to kill an enemy that solely exists to make you kill Solaire.