I think, it would have to be Ender's Game. Without revealing too much along the story, they missed so many key moments in Ender's "childhood" I ended up turning my TV off the first time I watched it. So what is your opinion?
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Judge dredd the comics are great but the first movie with Stallone was terrible but I'm glad they made Dredd that movie nailed it! Also the Toby McGuire spider man trilogy was god awful.