Star Wars has ion disruptors which rip apart any organic being or thing on a molecular level. Flood? gg.
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Tau infantry has a standard weapon that utilizes ion blasts that rip apart biological and non-biological matter at an atomic level. GG.
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The forerunners developed weapons with the same idea in mind. Take a look at forerunner weapons in Halo 4, many disintegrate their opponents, and were designed to do so so that the flood could not reanimate the fallen. And yet, the forerunners could not stop them. Because when you have a planet's worth of combat forms rushing you, your weapon's effectiveness against organics becomes secondary to how many you can kill before you're overwhelmed
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Idiocy.