Forerunners, Precursors, Reapers, the Imperium of Man (wh40k).
[spoiler]Reapers indoctrinate Imperium. Precursors use neural physics and stuff to assume control of Reapers. Forerunners support Precursors.
Man gets tech fixed up and gain title of Reclaimers, Reapers invade the Warp and indoctrinate everything, resulting in a 'calming' phase (reverting to [Place name to do with souls?] ). Precursors leave galaxy and go to sleep in a holiday mini-galaxy. Forerunners build Halo Array (improved, designed with ability to focus on one species or type of, can be focused into a local area blast < galaxy for less genocide) then sit in Shield Worlds while Mankind is dealing with everything (see 'If the Emperor had text to speech...' for an idea).[/spoiler]
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You win and tts rocks
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Good luck indoctrinating a dimension where laws of nature/physics are ever changing. I seriously doubt that they'd be able to handle even a warp storm. I doubt they'd be able to handle the Imperium either.
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Who knows. We've never seen the Precursors in a wibbly-wobbly situation before (I bet they may stabilize the 'verse, and Forerunners invent a giant space hoover?)... Then the Reapers may still live by sneaking about and nudging people and gods to do their bidding without knowing...
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The Chaos God's are omnipresent in the warp. A Lord of Change would probably be enough to wipe out most of the reaper fleet.
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Then again, Reaper Logic may irritate Chaos as a majority to the point where they end up among them, or worse, or better.
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The reapers would more than likely get corrupted.
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Not even the chaos gods would want to look upoun them, for they become that which is feared. That which is inevitable. Death in it's purest form. Their newer human-Reaper would literally resemble the Reaper (one with a scythe).
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You do realize they've destroyed multiple universes in their entirety? I don't think a single galaxy is really going to faze them.
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Bugger.